CONTACT

 

Knights Lab

MCB 6-124

420 Washington Ave SE

Minneapolis, MN 55455

(612) 5-MICROB (612-564-2762)

dknights@umn.edu

ABOUT

 

Dr. Dan Knights is an Assistant Professor in the Department of Computer Science and Engineering and the Biotechnology Institute at the University of Minnesota. The Knights lab models host-microbiome interactions in human disease, with labs in Minneapolis and Saint Paul. Knights is a PI with the Minnesota Supercomputing Institute.

© 2013-2014 Knights Lab, University of Minnesota

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March 25, 2016

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Immigrant Microbiome paper published in Cell

November 9, 2018

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Dan presents at the Microbiome R&D Businesses Collaboration Forum

October 2, 2014

Dr. Knights presented a talk on "Identifying Dysbiosis: Complexities of Microbiome Diagnostics" at the 2014 Microbiome R&D Business Collaboration Forum in San Diego. 

 

Abstract:

Given the complexity of the human microbiome and its links to a growing list of serious and prevalent diseases, the development of computational and experimental models that effectively characterize dysbiosis will advance medical research along numerous fronts. It is essential that we identify common underlying features across human microbiomes that explain the roles our gut microbiota play in modulating our health. We can in theory discover the mechanisms of pathogenesis in the microbiome if we collect the right data and analyze it with the right tools, but there are substantial computational and experimental challenges that need to be solved first. This presentation will introduce several major challenges in identifying and interpreting bacterial dysbiosis in human disease. The talk will then present contributions to solving several of these challenges using a tools from data mining and statistics.

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